Microsphere Tretinoin 0.1% Gel (MyTret) 15 gm is a potent retinoid treatment used for severe acne, post-acne scarring, deep pigmentation, and advanced anti-aging therapy. This formulation uses microsphere technology, enabling controlled, slow release of tretinoin to improve tolerability, even at this high-strength level.
🌡 In the Philippines, dermatologists prescribe 0.1% strength only to patients previously acclimated to lower strengths (0.025% or 0.04%), especially due to tropical humidity, higher sensitivity, and frequent sun exposure.
🧪 Strength & Technology Comparison
| Strength | Skin Type | Common Use | Irritation Level |
|---|---|---|---|
| 0.025% | Beginners | Mild acne | Low |
| 0.04% | Moderate acne | Texture | Moderate |
| 0.1% (this product) | Severe acne | Scars, aging | High – needs specialist care |
💡 Microsphere controls release over time → Less irritation compared to standard 0.1% tretinoin.
📌 Key Benefits
✔ Deep acne treatment (resistant/nodular)
✔ Reduces deep scars & hyperpigmentation
✔ Enhances collagen → anti-aging effect
✔ Improves uneven skin tone & rough texture
🚨 Warnings & Safety (Important in PH)
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Use only under dermatologist supervision.
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Apply at night only (pea-sized).
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Must use high SPF (50+) every morning.
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Not for beginners or sensitive skin.
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Avoid during pregnancy/breastfeeding.
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Expect purging for 2–4 weeks.
How to Use
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Start every 3rd night → alternate nights → daily if tolerated.
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Apply to completely dry face.
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Follow with moisturizer.
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Use sunscreen daily.
FAQs (10)
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What is Microsphere Tretinoin 0.1% Gel used for?
For severe acne, deep pigmentation, and advanced anti-aging therapy. -
Who should use 0.1% strength?
Only users already tolerant of lower tretinoin strengths under dermatologist supervision. -
Is it suitable for Filipino skin?
Yes, but due to high potency, must be monitored under proper prescription. -
Why microsphere technology?
It reduces irritation by releasing tretinoin gradually. -
How long to see results?
Improvement seen in 6–12 weeks for acne and skin texture. -
Can it cause purging?
Yes, especially at the beginning (2–4 weeks). -
Do I need sunscreen?
Yes, high SPF (50+) daily is mandatory. -
Can pregnant women use it?
No, tretinoin is not recommended during pregnancy. -
Should I moisturize after application?
Yes, to reduce dryness and peeling. -
Can it be used long-term?
Yes, with proper supervision and sun protection.
External Links (Authority)
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FDA Philippines – https://www.fda.gov.ph
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Philippine Dermatological Society – https://pds.org.ph
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DOH Philippines – https://doh.gov.ph
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WHO: Acne Prevalence Tropics – https://www.who.int
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FDA retinoid use guidelines – https://www.fda.gov.ph/fda-advisories/

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