🌞 Understanding the Difference
Both Tretinoin and Isotretinoin come from Vitamin A — but they work differently:
- Tretinoin works on the skin’s surface.
- Isotretinoin works from the inside out.
Let’s break it down — especially for Filipino skin types, which tend to be oily and acne-prone due to our humid weather.
🧴 Tretinoin (A-Ret Gel) – The Topical Retinoid
🩺 Buy A-Ret 0.1% Gel
🩺 Buy A-Ret 0.05% Gel
How it works:
Tretinoin helps your skin renew faster. It removes dead skin cells, unclogs pores, and prevents acne formation.
Best for:
- Whiteheads, blackheads, mild acne
- Skin texture and pigmentation
- Post-acne scars
Pros:
✅ Affordable
✅ Works for most acne-prone Filipinos
✅ Also improves wrinkles and brightness

Cons:
⚠️ Can cause mild peeling or dryness at first
💡 Tip: Apply at night, start every other day, and always wear sunscreen in the morning.
💊 Isotretinoin (Accufine Softgel Capsules) – The Oral Acne Solution
🩺 Buy Accufine 10mg
🩺 Buy Accufine 40mg
How it works:
Isotretinoin targets oil glands inside the skin. It reduces sebum (oil) production, shrinks pores, and stops acne from recurring.
Best for:
- Severe, cystic acne
- Acne that resists all other treatments
- Long-term prevention
Pros:
✅ Clears even the toughest acne
✅ Results last for years
✅ Prevents acne scarring
Cons:
⚠️ Needs doctor supervision
⚠️ Possible dryness or sensitivity
💊 Tip: Drink plenty of water and moisturize daily while on Accufine.
🔍 Tretinoin vs Isotretinoin: A Simple Comparison Table
| Feature | Tretinoin (A-Ret) | Isotretinoin (Accufine) |
|---|---|---|
| Type | Topical Gel | Oral Capsule |
| Use | Mild to moderate acne | Severe acne |
| How it works | Exfoliates skin & unclogs pores | Reduces oil glands internally |
| Results visible | 3–6 weeks | 1–3 months |
| Requires prescription? | Sometimes | Always |
| Side effects | Peeling, dryness | Dry lips, sensitivity |
| Cost range | 💰 Affordable | 💰💰 Moderate |
👩⚕️ Which One Should You Choose?
✅ Start with Tretinoin (A-Ret) if:
- You have mild to moderate acne
- You prefer topical treatment
- You want brighter, smoother skin
✅ Go for Isotretinoin (Accufine) if:
- You have severe, cystic, or persistent acne
- Other creams didn’t work
- You want long-term acne control
Some dermatologists even combine them — Isotretinoin for short-term clearing and Tretinoin for maintenance.
🌍 Why Buy from Palmer Wellness Hub
At Palmer Wellness Hub, all medicines are FDA-approved, authentic, and shipped safely across the Philippines.
You can order both A-Ret Gel and Accufine Capsules easily with nationwide delivery.
🛒 Visit → Acne & Pimple Care Collection
🔗 External References
- Philippine FDA – Retinoid Safety Guidelines
- American Academy of Dermatology – Acne Treatment Options
- Healthline – Tretinoin vs Isotretinoin Explained
- Rappler – Filipino Dermatologists on Acne Solutions
❓ FAQs
1️⃣ Can I use tretinoin and isotretinoin together?
Only under dermatologist guidance — usually not at the same time.
2️⃣ Is isotretinoin safe for Filipinos?
Yes, but must be prescribed and monitored for dryness or sensitivity.
3️⃣ Which gives faster results?
Isotretinoin clears cystic acne faster; tretinoin is slower but gentler.
4️⃣ Can I buy tretinoin without prescription?
Some strengths like A-Ret are available online via Palmer Wellness Hub.
5️⃣ Which one removes acne scars better?
Tretinoin helps with post-acne marks and texture.
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